Atopic Dermatitis Treatment with APG777
and APG990
Atopic Dermatitis Treatment with APG777
and APG990
Client:
Client:
Client:
Client:
Apogee Therapeutics is a clinical-stage biotechnology company that discovers and develops novel therapies for a range of inflammatory and immunological diseases. The company seeks to achieve this by focusing on established biologic drivers of disease and applying advanced antibody engineering to create product candidates with optimized properties that may overcome the limitations of existing therapies.
Apogee Therapeutics is a clinical-stage biotechnology company that discovers and develops novel therapies for a range of inflammatory and immunological diseases. The company seeks to achieve this by focusing on established biologic drivers of disease and applying advanced antibody engineering to create product candidates with optimized properties that may overcome the limitations of existing therapies.
Apogee Therapeutics is a clinical-stage biotechnology company that discovers and develops novel therapies for a range of inflammatory and immunological diseases. The company seeks to achieve this by focusing on established biologic drivers of disease and applying advanced antibody engineering to create product candidates with optimized properties that may overcome the limitations of existing therapies.
Apogee Therapeutics is a clinical-stage biotechnology company that discovers and develops novel therapies for a range of inflammatory and immunological diseases. The company seeks to achieve this by focusing on established biologic drivers of disease and applying advanced antibody engineering to create product candidates with optimized properties that may overcome the limitations of existing therapies.
Project Goal
Project Goal
Project Goal
Project Goal
Apogee Therapeutics required a 3D animation to explain the mechanisms of action (MoA) of its monoclonal antibodies, zumilokibart (APG777) and APG990, for the treatment of atopic dermatitis. The animation demonstrated how zumilokibart blocks IL-13 to reduce type 2 inflammation and how APG990 targets the OX40 ligand to modulate the immune response. It also illustrated Apogee’s antibody recycling mechanism, which extends therapeutic half-life. Designed for investors and healthcare professionals, the animation simplified complex biological pathways and highlighted the benefits of Apogee’s treatments.
See full animation.
Apogee Therapeutics required a 3D animation to explain the mechanisms of action (MoA) of its monoclonal antibodies, zumilokibart (APG777) and APG990, for the treatment of atopic dermatitis. The animation demonstrated how zumilokibart blocks IL-13 to reduce type 2 inflammation and how APG990 targets the OX40 ligand to modulate the immune response. It also illustrated Apogee’s antibody recycling mechanism, which extends therapeutic half-life. Designed for investors and healthcare professionals, the animation simplified complex biological pathways and highlighted the benefits of Apogee’s treatments.
See full animation.
Apogee Therapeutics required a 3D animation to explain the mechanisms of action (MoA) of its monoclonal antibodies, zumilokibart (APG777) and APG990, for the treatment of atopic dermatitis. The animation demonstrated how zumilokibart blocks IL-13 to reduce type 2 inflammation and how APG990 targets the OX40 ligand to modulate the immune response. It also illustrated Apogee’s antibody recycling mechanism, which extends therapeutic half-life. Designed for investors and healthcare professionals, the animation simplified complex biological pathways and highlighted the benefits of Apogee’s treatments.
See full animation.
Antibody molecules: zumilokibart (APG777) and APG990
Antibody molecules: zumilokibart (APG777) and APG990
Antibody molecules: zumilokibart (APG777) and APG990
APG777 internalized by cell
APG777 internalized by cell
APG777 internalized by cell
Atopic Dermatitis
Atopic Dermatitis
Atopic Dermatitis
“Incredible animations that really help bring our science to life. I strongly recommend Visual Science!”
“Incredible animations that really help bring our science to life. I strongly recommend Visual Science!”
“Incredible animations that really help bring our science to life. I strongly recommend Visual Science!”
“Incredible animations that really help bring our science to life. I strongly recommend Visual Science!”
Epidermis and Dermis are impacted by Atopic dermatitis
Epidermis and Dermis are impacted by Atopic dermatitis
Epidermis and Dermis are impacted by Atopic dermatitis
Zumilokibart binging to IL-13
Zumilokibart binging to IL-13
Zumilokibart binging to IL-13
IL-13 cytokine driving type 2 inflammatory signaling
IL-13 cytokine driving type 2 inflammatory signaling
IL-13 cytokine driving type 2 inflammatory signaling
The Process
The Process
Animation type:
Animation type:
3D Animation
3D Animation
Project timline:
Project timline:
7 weeks
Review:
Review:
3 zoom calls + 6 e-mail feedback sessions
3 zoom calls + 6 e-mail feedback sessions
Find out which of our 26 scientific animation options works best for investor relations and communications:
To bring Apogee Therapeutics’ research to life, we created a high-end 3D animation that visualized the complex molecular mechanisms underlying atopic dermatitis and its treatment with zumilokibart and APG990. Detailed 3D models illustrated skin barrier disruption caused by chronic inflammation, while dynamic molecular animations demonstrated how IL-13 and the OX40 ligand drive disease progression. Split-screen sequences were used throughout the animation to compare inflammatory pathways, treatment mechanisms, and therapeutic outcomes, providing a clear visual distinction between untreated and treated conditions. By leveraging cinematic 3D rendering and precise molecular interactions, we ensured the animation was both scientifically accurate and visually compelling.
High-End 3D Animation: Realistic molecular interactions and detailed skin models.
Molecular Visualization: Clear depiction of IL-13 and OX40 ligand signaling pathways.
Split Screens: Side-by-side comparisons of inflammation, treatment mechanisms, and outcomes.
Therapeutic Impact: Visualization of extended antibody half-life and reduced dosing frequency.
Why did we use this
animation type?
Why did we use this
animation type?
A high-end 3D animation was chosen to accurately depict the complex molecular interactions involved in atopic dermatitis and the treatments zumilokibart and APG990. Detailed 3D models of IL-13, OX40, and immune responses provided clarity while explaining intricate biological processes to both scientific and general audiences. The split-screen format enabled clear comparisons of the therapies’ mechanisms, highlighting their complementary roles in targeting type 1, type 2, and type 3 inflammation.
Outcome:
Outcome:
The final medical animation clearly conveyed the mechanisms of action of zumilokibart and APG990 in the treatment of atopic dermatitis. It simplified complex immune responses and showcased the therapies’ potential for long-lasting symptom relief with less frequent dosing. The animation successfully supported investor communications, educational outreach, and scientific presentations as part of broader medical communication services.
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“I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
"Visual Science was a great partner in the development and delivery of scientific animations; the combination of their understanding of the science and their artistic expertise resulted in a visually stunning and impactful video."
“Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
“Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
“We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
“The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
“The creativity, scientific competency and professionalism of the Visual Science team not only enabled the generation of high-quality images, but also made it a pleasure to work with them.”
"Incredible animations that really help bring our science to life. I strongly recommend Visual Science!"
“The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
"We were impressed with the Visual Science team's attention to detail and ability to extract key messages out of a complex scientific story. Their deep understanding of the science enabled them to turn our cryo-EM structures into a beautiful visual that shows the key aspects of the bridge recombination mechanism."
"The Visual Science team did an outstanding job delivering beautiful MOA videos for us. The animations and attention to detail were exceptional, and their flexibility throughout the process made a huge difference."
"Excellent work by the Visual Science team!"
"Excellent work and project management."
"Visual Science produces high quality animations to support our unique science with agility and speed. I do value their partnership and look forward to working on more projects with them."
"The VS team was outstanding to work with on this project. From the outset, the level of communication, organization, and attention to detail was exceptional. The VS team moved a complication MoA project forward on-schedule, with scientific rigor, and the result was a beautifully composed video that distilled complex biology in a visually accurate way. I highly recommend this team."
"Thank you very much for such a great deliverable on a very tight timeline. I have been doing things like this for a long time and your incorporation of the Atsena insights to this with a very fast turnaround is very much appreciated and impressive."
"Very responsive and efficient. Thank you!"
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“Fantastic team to partner with throughout the entire process. Excellent output and management!”
"Visual Science produced an excellent website with incredible imagery, working in a professional, efficient manner to create a stunning final product! They were engaged through every step of the process and were attentive to the ideas we had in mind for our website. They continue to work with us on all updates and requests in a timely and helpful manner!"
“Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
“We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.
“Visual Science has a unique ability to communicate complex science with both accuracy and visual impact. Their team combines scientific understanding with creativity, helping bring sophisticated biomedical concepts to life.”
“We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
“I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
"Visual Science was a great partner in the development and delivery of scientific animations; the combination of their understanding of the science and their artistic expertise resulted in a visually stunning and impactful video."
“Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
“Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
“We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
“The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
“The creativity, scientific competency and professionalism of the Visual Science team not only enabled the generation of high-quality images, but also made it a pleasure to work with them.”
"Incredible animations that really help bring our science to life. I strongly recommend Visual Science!"
“The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
"We were impressed with the Visual Science team's attention to detail and ability to extract key messages out of a complex scientific story. Their deep understanding of the science enabled them to turn our cryo-EM structures into a beautiful visual that shows the key aspects of the bridge recombination mechanism."
"The Visual Science team did an outstanding job delivering beautiful MOA videos for us. The animations and attention to detail were exceptional, and their flexibility throughout the process made a huge difference."
"Excellent work by the Visual Science team!"
"Excellent work and project management."
"Visual Science produces high quality animations to support our unique science with agility and speed. I do value their partnership and look forward to working on more projects with them."
"The VS team was outstanding to work with on this project. From the outset, the level of communication, organization, and attention to detail was exceptional. The VS team moved a complication MoA project forward on-schedule, with scientific rigor, and the result was a beautifully composed video that distilled complex biology in a visually accurate way. I highly recommend this team."
"Thank you very much for such a great deliverable on a very tight timeline. I have been doing things like this for a long time and your incorporation of the Atsena insights to this with a very fast turnaround is very much appreciated and impressive."
"Very responsive and efficient. Thank you!"
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Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
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Address
200 Vesey Street, 24th floor,
New York, NY 10281, USA
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
Contacts
Address
200 Vesey Street, 24th floor,
New York, NY 10281, USA
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
Contacts
Address
200 Vesey Street, 24th floor,
New York, NY 10281, USA
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
Contacts
Address
200 Vesey Street, 24th floor, New York, NY 10281, USA
© 2026, Visual Science. All rights reserved.
