3D MoA for a Cyclin A/B RxL Inhibitor
Client:
Circle Pharma is a clinical-stage biopharmaceutical company developing macrocycle therapies designed to target challenging intracellular proteins in cancer and other serious diseases. Through its proprietary platform, the company creates orally bioavailable macrocycles capable of addressing historically undruggable targets. Its oncology pipeline includes programs for advanced solid tumors, with particular focus on small-cell lung cancer and cancers driven by cell cycle dysregulation.
Circle Pharma is a clinical-stage biopharmaceutical company developing macrocycle therapies designed to target challenging intracellular proteins in cancer and other serious diseases. Through its proprietary platform, the company creates orally bioavailable macrocycles capable of addressing historically undruggable targets. Its oncology pipeline includes programs for advanced solid tumors, with particular focus on small-cell lung cancer and cancers driven by cell cycle dysregulation.
Client:
Project goal
To create a High-end 3D mechanism-of-action animation that clearly illustrates how CID-078 selectively inhibits Cyclin A/B–RxL interactions to disrupt cancer cell cycle progression in E2F-driven tumors.
CID-078 binding to the hydrophobic patch of Cyclin A–CDK2 and Cyclin B–CDK1 complexes
CID-078 blocks E2F, causing replication stress
Condensed chromosomes
“Visual Science is able to provide scientifically accurate and aesthetically pleasing animations. They are not creating a simple animation, but rather they are telling a story to accompany our journey in developing meaningful treatments for patients.”
“Visual Science is able to provide scientifically accurate and aesthetically pleasing animations. They are not creating a simple animation, but rather they are telling a story to accompany our journey in developing meaningful treatments for patients.”
Normal E2F inactivation vs. persistent E2F activity causing replication stress and DNA damage
DNA damage–induced cell death
E2F Binding to Cyclin A-CDK2
The Process
The Process
Animation type:
High-end 3D + 2D
Project timline:
10 weeks
Review:
5 zoom calls
Team:
Find out which of our 26 scientific animation options works best for investor relations and communications:
We began by working closely with the Circle Pharma team to refine the scientific narrative, translating a complex, unconventional cell-cycle mechanism into a clear visual sequence suitable for a ~90-second format. Because the therapy blocks cyclin function rather than directly inhibiting kinases, careful script and storyboard iteration were required to accurately depict both the molecular interaction and its downstream biological consequences.
To address the complexity of cell cycle biology, we implemented a dual visualization system. High-end 3D molecular environments portrayed cyclin complexes, chromatin architecture, and replication machinery with structural fidelity, while a restrained 2D infographic overlay guided viewers through cell cycle phases, checkpoints, and points of disruption—maintaining clarity without sacrificing scientific depth.
Outcome
The final animation delivered a clear and visually structured explanation of Circle Pharma’s differentiated approach to cell cycle intervention, translating a sophisticated biological cascade into an accessible narrative for investors and scientific audiences while maintaining strong scientific integrity and production quality.
Full animation
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We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
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The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
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Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
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Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
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The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
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I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
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We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
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Sr. Comms & IR Associate, Candel Tx
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We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
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Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
10/10
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Fantastic team to partner with throughout the entire process. Excellent output and management.
Global Marketing Director, Pfizer
10/10
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We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
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The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
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Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
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The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
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Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
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We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
10/10
“
Fantastic team to partner with throughout the entire process. Excellent output and management.
Global Marketing Director, Pfizer
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
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Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
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10/10
“
Fantastic team to partner with throughout the entire process. Excellent output and management.
Global Marketing Director, Pfizer
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
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Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
10/10
“
Fantastic team to partner with throughout the entire process. Excellent output and management.
Global Marketing Director, Pfizer
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
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Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
10/10
“
Fantastic team to partner with throughout the entire process. Excellent output and management.
Global Marketing Director, Pfizer
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
“
Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
10/10
“
Fantastic team to partner with throughout the entire process. Excellent output and management.
Global Marketing Director, Pfizer
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
“
Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
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Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
