3D MoA Animation on Targeting DR3 in the TL1A Pathway

We worked closely with the Shattuck Labs team to translate the immunological pathway into a clear and structured visual narrative. The animation was designed to move seamlessly from whole-body anatomy to tissue and molecular scales, establishing the clinical context of inflammatory bowel disease before focusing on the TL1A/DR3 signaling cascade. Particular care was taken to accurately depict the differential expression patterns of TL1A and DR3, visually reinforcing the distinction between localized ligand activity and broad receptor presence throughout inflamed and non-inflamed tissue.

A split-screen framework was developed to directly compare DR3 blockade with TL1A blockade, allowing viewers to clearly understand differences in pathway inhibition, residual activation, and immune complex formation. High-end 3D molecular modeling was used to portray ligand–receptor binding, cytokine release, fibrosis progression, and antibody interactions with structural credibility. This layered approach ensured that key biological distinctions — including tissue retention, dynamic ligand expression, and immunogenicity risk — were communicated with both scientific precision and visual clarity. We also developed a supporting presentation deck and website, with the visual language established in the MoA animation informing the design and scientific storytelling across these additional materials.