Plixorafenib Redefines BRAF Mutation Targeting
Plixorafenib Redefines BRAF Mutation Targeting
Plixorafenib Redefines BRAF Mutation Targeting
Plixorafenib Redefines BRAF Mutation Targeting
Client:
ForeBio is a precision oncology company developing targeted therapies for difficult-to-treat cancers. Its lead asset, plixorafenib, is a next-generation BRAF inhibitor designed to address a broad range of BRAF mutations beyond Class I (V600) without causing paradoxical activation of the MAPK cascade.
ForeBio is a precision oncology company developing targeted therapies for difficult-to-treat cancers. Its lead asset, plixorafenib, is a next-generation BRAF inhibitor designed to address a broad range of BRAF mutations beyond Class I (V600) without causing paradoxical activation of the MAPK cascade.
ForeBio is a precision oncology company developing targeted therapies for difficult-to-treat cancers. Its lead asset, plixorafenib, is a next-generation BRAF inhibitor designed to address a broad range of BRAF mutations beyond Class I (V600) without causing paradoxical activation of the MAPK cascade.
ForeBio is a precision oncology company developing targeted therapies for difficult-to-treat cancers. Its lead asset, plixorafenib, is a next-generation BRAF inhibitor designed to address a broad range of BRAF mutations beyond Class I (V600) without causing paradoxical activation of the MAPK cascade.
Client:
Project Goal
Project Goal
Project Goal
Project Goal
To support ForeBio’s investor relations, corporate communications, and industry presentations, we developed a concise mechanism-of-action (MoA) animation for plixorafenib that illustrates its competitive advantages. By balancing high-detail molecular visualization with accessibility, the animation enabled both scientific and non-scientific stakeholders to quickly grasp the key takeaways.
See full animation.
To support ForeBio’s investor relations, corporate communications, and industry presentations, we developed a concise mechanism-of-action (MoA) animation for plixorafenib that illustrates its competitive advantages. By balancing high-detail molecular visualization with accessibility, the animation enabled both scientific and non-scientific stakeholders to quickly grasp the key takeaways.
See full animation.
To support ForeBio’s investor relations, corporate communications, and industry presentations, we developed a concise mechanism-of-action (MoA) animation for plixorafenib that illustrates its competitive advantages. By balancing high-detail molecular visualization with accessibility, the animation enabled both scientific and non-scientific stakeholders to quickly grasp the key takeaways.
See full animation.
To support ForeBio’s investor relations, corporate communications, and industry presentations, we developed a concise mechanism-of-action (MoA) animation for plixorafenib that illustrates its competitive advantages. By balancing high-detail molecular visualization with accessibility, the animation enabled both scientific and non-scientific stakeholders to quickly grasp the key takeaways.
See full animation.
Paradoxical activation of the MAPK cascade
Paradoxical activation of the MAPK cascade
Paradoxical activation of the MAPK cascade
Class III Dimers: RAS, BRAF, and CRAF
Class III Dimers: RAS, BRAF, and CRAF
Class III Dimers: RAS, BRAF, and CRAF
Class III Dimers: RAS, BRAF, and CRAF
Plixorafenib targeting mutated BRAF
Plixorafenib targeting mutated BRAF
Plixorafenib targeting mutated BRAF
Plixorafenib targeting mutated BRAF
“Excellent collaboration to complete a beautiful final animation!”
“Excellent collaboration to complete a beautiful final animation!”
“Excellent collaboration to complete a beautiful final animation!”
“Excellent collaboration to complete a beautiful final animation!”
Executive Director and Lead of Medical Affairs
Executive Director and
Lead of Medical Affairs
BRAF dimers interact with RAS proteins in the beginning of the MAPK signaling cascade
BRAF dimers interact with RAS proteins in the beginning of the MAPK signaling cascade
BRAF dimers interact with RAS proteins in the beginning of the MAPK signaling cascade
BRAF dimers interact with RAS proteins in the beginning of the MAPK signaling cascade
Plixorafenib targets BRAF-CRAF heterodimers
Plixorafenib targets BRAF-CRAF heterodimers
Plixorafenib targets BRAF-CRAF heterodimers
Plixorafenib targets BRAF-CRAF heterodimers
Destruction of Cancer cells
Destruction of Cancer cells
Destruction of Cancer cells
Destruction of Cancer cells
The Process
The Process
The Process
The Process
Animation type:
Animation type:
Animation type:
3D + High End 3D
3D + High End 3D
3D + High End 3D
Project timline:
Project timline:
Project timline:
7 weeks
7 weeks
7 weeks
Review:
Review:
Review:
3 zoom calls + 7 e-mail feedback sessions
3 zoom calls + 7 e-mail feedback sessions
3 zoom calls + 7 e-mail feedback sessions
Find out which of our 26 scientific animation options works best for investor relations and communications:
Find out which of our 26 scientific animation options works best for investor relations and communications:
Find out which of our 26 scientific animation options works best for investor relations and communications:
To accurately visualize BRAF inhibitors and their effects, we combined high-end molecular modeling with clear, structured storytelling. The animation depicted how plixorafenib interacts with the BRAF signaling cascade, ensuring scientific accuracy while maintaining accessibility.
Communicating the mechanism of action and competitive advantages of plixorafenib is particularly challenging, as BRAF targeting involves significant nuances, including paradoxical activation of the MAPK cascade and the presence of different RAF mutation classes and dimerization states. To address this complexity, we applied several complementary approaches to ensure an accurate and effective communication asset.
High-End 3D Molecular Animation: We used molecular dynamics simulations and structural modeling to depict precise protein conformations, inhibitor binding, and phosphorylation events. This project employed a more detailed molecular approach than our previous conceptual animations.
Visual Overlays: Simplified schematic 2D overlays mirrored the molecular sequences, breaking down key interactions for easier comprehension. These were combined with a color-coded tagging system to consistently highlight critical molecular components.
Brand Integration: The animation aesthetics were aligned with ForeBio’s corporate style guide, refining protein stylization to match the brand while preserving scientific precision.
To accurately visualize BRAF inhibitors and their effects, we combined high-end molecular modeling with clear, structured storytelling. The animation depicted how plixorafenib interacts with the BRAF signaling cascade, ensuring scientific accuracy while maintaining accessibility.
Communicating the mechanism of action and competitive advantages of plixorafenib is particularly challenging, as BRAF targeting involves significant nuances, including paradoxical activation of the MAPK cascade and the presence of different RAF mutation classes and dimerization states. To address this complexity, we applied several complementary approaches to ensure an accurate and effective communication asset.
High-End 3D Molecular Animation: We used molecular dynamics simulations and structural modeling to depict precise protein conformations, inhibitor binding, and phosphorylation events. This project employed a more detailed molecular approach than our previous conceptual animations.
Visual Overlays: Simplified schematic 2D overlays mirrored the molecular sequences, breaking down key interactions for easier comprehension. These were combined with a color-coded tagging system to consistently highlight critical molecular components.
Brand Integration: The animation aesthetics were aligned with ForeBio’s corporate style guide, refining protein stylization to match the brand while preserving scientific precision.
To accurately visualize BRAF inhibitors and their effects, we combined high-end molecular modeling with clear, structured storytelling. The animation depicted how plixorafenib interacts with the BRAF signaling cascade, ensuring scientific accuracy while maintaining accessibility.
Communicating the mechanism of action and competitive advantages of plixorafenib is particularly challenging, as BRAF targeting involves significant nuances, including paradoxical activation of the MAPK cascade and the presence of different RAF mutation classes and dimerization states. To address this complexity, we applied several complementary approaches to ensure an accurate and effective communication asset.
High-End 3D Molecular Animation: We used molecular dynamics simulations and structural modeling to depict precise protein conformations, inhibitor binding, and phosphorylation events. This project employed a more detailed molecular approach than our previous conceptual animations.
Visual Overlays: Simplified schematic 2D overlays mirrored the molecular sequences, breaking down key interactions for easier comprehension. These were combined with a color-coded tagging system to consistently highlight critical molecular components.
Brand Integration: The animation aesthetics were aligned with ForeBio’s corporate style guide, refining protein stylization to match the brand while preserving scientific precision.
To accurately visualize BRAF inhibitors and their effects, we combined high-end molecular modeling with clear, structured storytelling. The animation depicted how plixorafenib interacts with the BRAF signaling cascade, ensuring scientific accuracy while maintaining accessibility.
Communicating the mechanism of action and competitive advantages of plixorafenib is particularly challenging, as BRAF targeting involves significant nuances, including paradoxical activation of the MAPK cascade and the presence of different RAF mutation classes and dimerization states. To address this complexity, we applied several complementary approaches to ensure an accurate and effective communication asset.
High-End 3D Molecular Animation: We used molecular dynamics simulations and structural modeling to depict precise protein conformations, inhibitor binding, and phosphorylation events. This project employed a more detailed molecular approach than our previous conceptual animations.
Visual Overlays: Simplified schematic 2D overlays mirrored the molecular sequences, breaking down key interactions for easier comprehension. These were combined with a color-coded tagging system to consistently highlight critical molecular components.
Brand Integration: The animation aesthetics were aligned with ForeBio’s corporate style guide, refining protein stylization to match the brand while preserving scientific precision.
Why did we use this
animation type?
Why did we use
this animation type?
Why did we use this
animation type?
Why did we use this
animation type?
We used detailed 3D molecular animation to precisely depict plixorafenib’s interactions within the BRAF signaling cascade. Although the project did not formally adopt a full high-end style, we applied our molecular modeling expertise to reconstruct complete structures of key proteins, including unresolved intrinsically disordered regions. Molecular modeling and simulations ensured scientific accuracy, while 2D overlays simplified complex interactions for broader audiences. Cinematic techniques—such as dynamic lighting and seamless transitions—enhanced engagement, and brand-aligned visuals reflected ForeBio’s well-developed corporate style, which extends beyond color to include specific preferences for 3D visual aesthetics.
We used detailed 3D molecular animation to precisely depict plixorafenib’s interactions within the BRAF signaling cascade. Although the project did not formally adopt a full high-end style, we applied our molecular modeling expertise to reconstruct complete structures of key proteins, including unresolved intrinsically disordered regions. Molecular modeling and simulations ensured scientific accuracy, while 2D overlays simplified complex interactions for broader audiences. Cinematic techniques—such as dynamic lighting and seamless transitions—enhanced engagement, and brand-aligned visuals reflected ForeBio’s well-developed corporate style, which extends beyond color to include specific preferences for 3D visual aesthetics.
We used detailed 3D molecular animation to precisely depict plixorafenib’s interactions within the BRAF signaling cascade. Although the project did not formally adopt a full high-end style, we applied our molecular modeling expertise to reconstruct complete structures of key proteins, including unresolved intrinsically disordered regions. Molecular modeling and simulations ensured scientific accuracy, while 2D overlays simplified complex interactions for broader audiences. Cinematic techniques—such as dynamic lighting and seamless transitions—enhanced engagement, and brand-aligned visuals reflected ForeBio’s well-developed corporate style, which extends beyond color to include specific preferences for 3D visual aesthetics.
We used detailed 3D molecular animation to precisely depict plixorafenib’s interactions within the BRAF signaling cascade. Although the project did not formally adopt a full high-end style, we applied our molecular modeling expertise to reconstruct complete structures of key proteins, including unresolved intrinsically disordered regions. Molecular modeling and simulations ensured scientific accuracy, while 2D overlays simplified complex interactions for broader audiences. Cinematic techniques—such as dynamic lighting and seamless transitions—enhanced engagement, and brand-aligned visuals reflected ForeBio’s well-developed corporate style, which extends beyond color to include specific preferences for 3D visual aesthetics.
Outcome:
Outcome:
Outcome:
he animation delivered a clear and engaging depiction of BRAF inhibitors for both scientific and business audiences. By blending detailed 3D modeling with intuitive 2D elements, it became a versatile asset for investor decks, corporate presentations, and conferences, supporting scientific visualization services for pharma. Successfully deployed at a key congress, the animation reinforced ForeBio’s messaging and helped drive interest in its oncology approach.
he animation delivered a clear and engaging depiction of BRAF inhibitors for both scientific and business audiences. By blending detailed 3D modeling with intuitive 2D elements, it became a versatile asset for investor decks, corporate presentations, and conferences, supporting scientific visualization services for pharma. Successfully deployed at a key congress, the animation reinforced ForeBio’s messaging and helped drive interest in its oncology approach.
he animation delivered a clear and engaging depiction of BRAF inhibitors for both scientific and business audiences. By blending detailed 3D modeling with intuitive 2D elements, it became a versatile asset for investor decks, corporate presentations, and conferences, supporting scientific visualization services for pharma. Successfully deployed at a key congress, the animation reinforced ForeBio’s messaging and helped drive interest in its oncology approach.
he animation delivered a clear and engaging depiction of BRAF inhibitors for both scientific and business audiences. By blending detailed 3D modeling with intuitive 2D elements, it became a versatile asset for investor decks, corporate presentations, and conferences, supporting scientific visualization services for pharma. Successfully deployed at a key congress, the animation reinforced ForeBio’s messaging and helped drive interest in its oncology approach.
Full animation
Full animation
Full animation
Case Study Animation
You may also want to see
You may also want to see
You may also want to see
Contact us
“Fantastic team to partner with throughout the entire process. Excellent output and management!”
"Visual Science produced an excellent website with incredible imagery, working in a professional, efficient manner to create a stunning final product! They were engaged through every step of the process and were attentive to the ideas we had in mind for our website. They continue to work with us on all updates and requests in a timely and helpful manner!"
“Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
“We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.
“Visual Science has a unique ability to communicate complex science with both accuracy and visual impact. Their team combines scientific understanding with creativity, helping bring sophisticated biomedical concepts to life.”
“We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
“I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
"Visual Science was a great partner in the development and delivery of scientific animations; the combination of their understanding of the science and their artistic expertise resulted in a visually stunning and impactful video."
“Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
“Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
“We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
“The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
“The creativity, scientific competency and professionalism of the Visual Science team not only enabled the generation of high-quality images, but also made it a pleasure to work with them.”
"Incredible animations that really help bring our science to life. I strongly recommend Visual Science!"
“The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
"We were impressed with the Visual Science team's attention to detail and ability to extract key messages out of a complex scientific story. Their deep understanding of the science enabled them to turn our cryo-EM structures into a beautiful visual that shows the key aspects of the bridge recombination mechanism."
"The Visual Science team did an outstanding job delivering beautiful MOA videos for us. The animations and attention to detail were exceptional, and their flexibility throughout the process made a huge difference."
"Excellent work by the Visual Science team!"
"Excellent work and project management."
"Visual Science produces high quality animations to support our unique science with agility and speed. I do value their partnership and look forward to working on more projects with them."
"The VS team was outstanding to work with on this project. From the outset, the level of communication, organization, and attention to detail was exceptional. The VS team moved a complication MoA project forward on-schedule, with scientific rigor, and the result was a beautifully composed video that distilled complex biology in a visually accurate way. I highly recommend this team."
"Thank you very much for such a great deliverable on a very tight timeline. I have been doing things like this for a long time and your incorporation of the Atsena insights to this with a very fast turnaround is very much appreciated and impressive."
"Very responsive and efficient. Thank you!"
Contact us
Contact us
“Fantastic team to partner with throughout the entire process. Excellent output and management!”
"Visual Science produced an excellent website with incredible imagery, working in a professional, efficient manner to create a stunning final product! They were engaged through every step of the process and were attentive to the ideas we had in mind for our website. They continue to work with us on all updates and requests in a timely and helpful manner!"
“Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
“We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.
“Visual Science has a unique ability to communicate complex science with both accuracy and visual impact. Their team combines scientific understanding with creativity, helping bring sophisticated biomedical concepts to life.”
“We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
“I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
"Visual Science was a great partner in the development and delivery of scientific animations; the combination of their understanding of the science and their artistic expertise resulted in a visually stunning and impactful video."
“Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
“Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
“We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
“The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
“The creativity, scientific competency and professionalism of the Visual Science team not only enabled the generation of high-quality images, but also made it a pleasure to work with them.”
"Incredible animations that really help bring our science to life. I strongly recommend Visual Science!"
“The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
"We were impressed with the Visual Science team's attention to detail and ability to extract key messages out of a complex scientific story. Their deep understanding of the science enabled them to turn our cryo-EM structures into a beautiful visual that shows the key aspects of the bridge recombination mechanism."
"The Visual Science team did an outstanding job delivering beautiful MOA videos for us. The animations and attention to detail were exceptional, and their flexibility throughout the process made a huge difference."
"Excellent work by the Visual Science team!"
"Excellent work and project management."
"Visual Science produces high quality animations to support our unique science with agility and speed. I do value their partnership and look forward to working on more projects with them."
"The VS team was outstanding to work with on this project. From the outset, the level of communication, organization, and attention to detail was exceptional. The VS team moved a complication MoA project forward on-schedule, with scientific rigor, and the result was a beautifully composed video that distilled complex biology in a visually accurate way. I highly recommend this team."
"Thank you very much for such a great deliverable on a very tight timeline. I have been doing things like this for a long time and your incorporation of the Atsena insights to this with a very fast turnaround is very much appreciated and impressive."
"Very responsive and efficient. Thank you!"
Contact us
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
Contacts
Address
200 Vesey Street, 24th floor,
New York, NY 10281, USA
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
Contacts
Address
200 Vesey Street, 24th floor, New York, NY 10281, USA
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
Contacts
Address
200 Vesey Street, 24th floor,
New York, NY 10281, USA
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
Contacts
Address
200 Vesey Street, 24th floor,
New York, NY 10281, USA
© 2026, Visual Science. All rights reserved.
