Plixorafenib Redefines BRAF Mutation Targeting
Plixorafenib Redefines BRAF Mutation Targeting
Plixorafenib Redefines BRAF Mutation Targeting
Plixorafenib Redefines BRAF Mutation Targeting
Client:
ForeBio is a precision oncology company developing targeted therapies for difficult-to-treat cancers. Its lead asset, plixorafenib, is a next-generation BRAF inhibitor designed to address a broad range of BRAF mutations beyond Class I (V600) without causing paradoxical activation of the MAPK cascade.
ForeBio is a precision oncology company developing targeted therapies for difficult-to-treat cancers. Its lead asset, plixorafenib, is a next-generation BRAF inhibitor designed to address a broad range of BRAF mutations beyond Class I (V600) without causing paradoxical activation of the MAPK cascade.
ForeBio is a precision oncology company developing targeted therapies for difficult-to-treat cancers. Its lead asset, plixorafenib, is a next-generation BRAF inhibitor designed to address a broad range of BRAF mutations beyond Class I (V600) without causing paradoxical activation of the MAPK cascade.
ForeBio is a precision oncology company developing targeted therapies for difficult-to-treat cancers. Its lead asset, plixorafenib, is a next-generation BRAF inhibitor designed to address a broad range of BRAF mutations beyond Class I (V600) without causing paradoxical activation of the MAPK cascade.
Client:
Project Goal
Project Goal
Project Goal
Project Goal
To support ForeBio’s investor relations, corporate communications, and industry presentations, we developed a concise mechanism-of-action (MoA) animation for plixorafenib that illustrates its competitive advantages. By balancing high-detail molecular visualization with accessibility, the animation enabled both scientific and non-scientific stakeholders to quickly grasp the key takeaways.
See full animation.
To support ForeBio’s investor relations, corporate communications, and industry presentations, we developed a concise mechanism-of-action (MoA) animation for plixorafenib that illustrates its competitive advantages. By balancing high-detail molecular visualization with accessibility, the animation enabled both scientific and non-scientific stakeholders to quickly grasp the key takeaways.
See full animation.
To support ForeBio’s investor relations, corporate communications, and industry presentations, we developed a concise mechanism-of-action (MoA) animation for plixorafenib that illustrates its competitive advantages. By balancing high-detail molecular visualization with accessibility, the animation enabled both scientific and non-scientific stakeholders to quickly grasp the key takeaways.
See full animation.
To support ForeBio’s investor relations, corporate communications, and industry presentations, we developed a concise mechanism-of-action (MoA) animation for plixorafenib that illustrates its competitive advantages. By balancing high-detail molecular visualization with accessibility, the animation enabled both scientific and non-scientific stakeholders to quickly grasp the key takeaways.
See full animation.
Paradoxical activation of the MAPK cascade
Paradoxical activation of the MAPK cascade
Paradoxical activation of the MAPK cascade
Paradoxical activation of the MAPK cascade
Class III Dimers: RAS, BRAF, and CRAF
Class III Dimers: RAS, BRAF, and CRAF
Class III Dimers: RAS, BRAF, and CRAF
Class III Dimers: RAS, BRAF, and CRAF
Plixorafenib targeting mutated BRAF
Plixorafenib targeting mutated BRAF
Plixorafenib targeting mutated BRAF
Plixorafenib targeting mutated BRAF
“Excellent collaboration to complete a beautiful final animation!”
“Excellent collaboration to complete a beautiful final animation!”
“Excellent collaboration to complete a beautiful final animation!”
“Excellent collaboration to complete a beautiful final animation!”
Executive Director and Lead of Medical Affairs
Executive Director and
Lead of Medical Affairs
BRAF dimers interact with RAS proteins in the beginning of the MAPK signaling cascade
BRAF dimers interact with RAS proteins in the beginning of the MAPK signaling cascade
BRAF dimers interact with RAS proteins in the beginning of the MAPK signaling cascade
BRAF dimers interact with RAS proteins in the beginning of the MAPK signaling cascade
Plixorafenib targets BRAF-CRAF heterodimers
Plixorafenib targets BRAF-CRAF heterodimers
Plixorafenib targets BRAF-CRAF heterodimers
Plixorafenib targets BRAF-CRAF heterodimers
Destruction of Cancer cells
Destruction of Cancer cells
Destruction of Cancer cells
Destruction of Cancer cells
The Process
The Process
The Process
The Process
Animation type:
Animation type:
Animation type:
Animation type:
3D + High End 3D
3D + High End 3D
3D + High End 3D
3D + High End 3D
Project timline:
Project timline:
Project timline:
Project timline:
7 weeks
7 weeks
7 weeks
7 weeks
Review:
Review:
Review:
Review:
3 zoom calls + 7 e-mail feedback sessions
3 zoom calls + 7 e-mail feedback sessions
3 zoom calls + 7 e-mail feedback sessions
3 zoom calls + 7 e-mail feedback sessions
Team:
Find out which of our 26 scientific animation options works best for investor relations and communications:
Find out which of our 26 scientific animation options works best for investor relations and communications:
Find out which of our 26 scientific animation options works best for investor relations and communications:
Find out which of our 26 scientific animation options works best for investor relations and communications:
To accurately visualize BRAF inhibitors and their effects, we combined high-end molecular modeling with clear, structured storytelling. The animation depicted how plixorafenib interacts with the BRAF signaling cascade, ensuring scientific accuracy while maintaining accessibility.
Communicating the mechanism of action and competitive advantages of plixorafenib is particularly challenging, as BRAF targeting involves significant nuances, including paradoxical activation of the MAPK cascade and the presence of different RAF mutation classes and dimerization states. To address this complexity, we applied several complementary approaches to ensure an accurate and effective communication asset.
High-End 3D Molecular Animation: We used molecular dynamics simulations and structural modeling to depict precise protein conformations, inhibitor binding, and phosphorylation events. This project employed a more detailed molecular approach than our previous conceptual animations.
Visual Overlays: Simplified schematic 2D overlays mirrored the molecular sequences, breaking down key interactions for easier comprehension. These were combined with a color-coded tagging system to consistently highlight critical molecular components.
Brand Integration: The animation aesthetics were aligned with ForeBio’s corporate style guide, refining protein stylization to match the brand while preserving scientific precision.
To accurately visualize BRAF inhibitors and their effects, we combined high-end molecular modeling with clear, structured storytelling. The animation depicted how plixorafenib interacts with the BRAF signaling cascade, ensuring scientific accuracy while maintaining accessibility.
Communicating the mechanism of action and competitive advantages of plixorafenib is particularly challenging, as BRAF targeting involves significant nuances, including paradoxical activation of the MAPK cascade and the presence of different RAF mutation classes and dimerization states. To address this complexity, we applied several complementary approaches to ensure an accurate and effective communication asset.
High-End 3D Molecular Animation: We used molecular dynamics simulations and structural modeling to depict precise protein conformations, inhibitor binding, and phosphorylation events. This project employed a more detailed molecular approach than our previous conceptual animations.
Visual Overlays: Simplified schematic 2D overlays mirrored the molecular sequences, breaking down key interactions for easier comprehension. These were combined with a color-coded tagging system to consistently highlight critical molecular components.
Brand Integration: The animation aesthetics were aligned with ForeBio’s corporate style guide, refining protein stylization to match the brand while preserving scientific precision.
To accurately visualize BRAF inhibitors and their effects, we combined high-end molecular modeling with clear, structured storytelling. The animation depicted how plixorafenib interacts with the BRAF signaling cascade, ensuring scientific accuracy while maintaining accessibility.
Communicating the mechanism of action and competitive advantages of plixorafenib is particularly challenging, as BRAF targeting involves significant nuances, including paradoxical activation of the MAPK cascade and the presence of different RAF mutation classes and dimerization states. To address this complexity, we applied several complementary approaches to ensure an accurate and effective communication asset.
High-End 3D Molecular Animation: We used molecular dynamics simulations and structural modeling to depict precise protein conformations, inhibitor binding, and phosphorylation events. This project employed a more detailed molecular approach than our previous conceptual animations.
Visual Overlays: Simplified schematic 2D overlays mirrored the molecular sequences, breaking down key interactions for easier comprehension. These were combined with a color-coded tagging system to consistently highlight critical molecular components.
Brand Integration: The animation aesthetics were aligned with ForeBio’s corporate style guide, refining protein stylization to match the brand while preserving scientific precision.
To accurately visualize BRAF inhibitors and their effects, we combined high-end molecular modeling with clear, structured storytelling. The animation depicted how plixorafenib interacts with the BRAF signaling cascade, ensuring scientific accuracy while maintaining accessibility.
Communicating the mechanism of action and competitive advantages of plixorafenib is particularly challenging, as BRAF targeting involves significant nuances, including paradoxical activation of the MAPK cascade and the presence of different RAF mutation classes and dimerization states. To address this complexity, we applied several complementary approaches to ensure an accurate and effective communication asset.
High-End 3D Molecular Animation: We used molecular dynamics simulations and structural modeling to depict precise protein conformations, inhibitor binding, and phosphorylation events. This project employed a more detailed molecular approach than our previous conceptual animations.
Visual Overlays: Simplified schematic 2D overlays mirrored the molecular sequences, breaking down key interactions for easier comprehension. These were combined with a color-coded tagging system to consistently highlight critical molecular components.
Brand Integration: The animation aesthetics were aligned with ForeBio’s corporate style guide, refining protein stylization to match the brand while preserving scientific precision.
Why did we use this
animation type?
Why did we use
this animation type?
Why did we use this
animation type?
Why did we use this
animation type?
We used detailed 3D molecular animation to precisely depict plixorafenib’s interactions within the BRAF signaling cascade. Although the project did not formally adopt a full high-end style, we applied our molecular modeling expertise to reconstruct complete structures of key proteins, including unresolved intrinsically disordered regions. Molecular modeling and simulations ensured scientific accuracy, while 2D overlays simplified complex interactions for broader audiences. Cinematic techniques—such as dynamic lighting and seamless transitions—enhanced engagement, and brand-aligned visuals reflected ForeBio’s well-developed corporate style, which extends beyond color to include specific preferences for 3D visual aesthetics.
We used detailed 3D molecular animation to precisely depict plixorafenib’s interactions within the BRAF signaling cascade. Although the project did not formally adopt a full high-end style, we applied our molecular modeling expertise to reconstruct complete structures of key proteins, including unresolved intrinsically disordered regions. Molecular modeling and simulations ensured scientific accuracy, while 2D overlays simplified complex interactions for broader audiences. Cinematic techniques—such as dynamic lighting and seamless transitions—enhanced engagement, and brand-aligned visuals reflected ForeBio’s well-developed corporate style, which extends beyond color to include specific preferences for 3D visual aesthetics.
We used detailed 3D molecular animation to precisely depict plixorafenib’s interactions within the BRAF signaling cascade. Although the project did not formally adopt a full high-end style, we applied our molecular modeling expertise to reconstruct complete structures of key proteins, including unresolved intrinsically disordered regions. Molecular modeling and simulations ensured scientific accuracy, while 2D overlays simplified complex interactions for broader audiences. Cinematic techniques—such as dynamic lighting and seamless transitions—enhanced engagement, and brand-aligned visuals reflected ForeBio’s well-developed corporate style, which extends beyond color to include specific preferences for 3D visual aesthetics.
We used detailed 3D molecular animation to precisely depict plixorafenib’s interactions within the BRAF signaling cascade. Although the project did not formally adopt a full high-end style, we applied our molecular modeling expertise to reconstruct complete structures of key proteins, including unresolved intrinsically disordered regions. Molecular modeling and simulations ensured scientific accuracy, while 2D overlays simplified complex interactions for broader audiences. Cinematic techniques—such as dynamic lighting and seamless transitions—enhanced engagement, and brand-aligned visuals reflected ForeBio’s well-developed corporate style, which extends beyond color to include specific preferences for 3D visual aesthetics.
Outcome:
Outcome:
Outcome:
Outcome:
The animation delivered a clear and engaging depiction of BRAF inhibitors for both scientific and business audiences. By blending detailed 3D modeling with intuitive 2D elements, it became a versatile asset for investor decks, corporate presentations, and conferences. Successfully deployed at a key congress, the animation reinforced ForeBio’s messaging and helped drive interest in its oncology approach.
The animation delivered a clear and engaging depiction of BRAF inhibitors for both scientific and business audiences. By blending detailed 3D modeling with intuitive 2D elements, it became a versatile asset for investor decks, corporate presentations, and conferences. Successfully deployed at a key congress, the animation reinforced ForeBio’s messaging and helped drive interest in its oncology approach.
The animation delivered a clear and engaging depiction of BRAF inhibitors for both scientific and business audiences. By blending detailed 3D modeling with intuitive 2D elements, it became a versatile asset for investor decks, corporate presentations, and conferences. Successfully deployed at a key congress, the animation reinforced ForeBio’s messaging and helped drive interest in its oncology approach.
The animation delivered a clear and engaging depiction of BRAF inhibitors for both scientific and business audiences. By blending detailed 3D modeling with intuitive 2D elements, it became a versatile asset for investor decks, corporate presentations, and conferences. Successfully deployed at a key congress, the animation reinforced ForeBio’s messaging and helped drive interest in its oncology approach.
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The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
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Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
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Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
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The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
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I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
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The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
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Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
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Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
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The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
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I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
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We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
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Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
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We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
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Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
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The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
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I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
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We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
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Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
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I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
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We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
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Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
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Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
