Metatide peptide 3D mechanism of action animation

N1 Life is a biotech company that originated as a Stanford University spinout start-up to develop innovative tissue-focused drug delivery technologies for new therapeutics to address unmet medical needs.

Project goal

Create a short eye-catching 3D MoA animation for investor communication.

Tumor sites in the digestive tract

Peptide-drug conjugate in disordered conformation

Normal vs tumor tissue in esophagus

"It has been an eye-opening journey for us. As bench scientist, we seem to be quite far a way from "art". We basically just described our MOA in the language we are familiar with, then we received super cute hand-drawn illustrations that translated our plain language to color for graphics.

We are amazed by the detailed and sophisticated work conducted by Visual Science. A short animation is actually built up with multilayer of science, molecular dynamics, and modern art. During the process of completing the project, Visual Science team really tried their best to integrate our ideas. That's amazing.”

Xiaoyu Zang (Janice), PhD

Co-Founder & CEO, N1 Life

Delivered drug hits the target

Peptide-drug conjugate in helical conformation

PDC linker activation

The Process

Animation type:

Semistatic 3D + High-End 3D

Project timline:

7 weeks

Team

Review:

4 zoom calls + 4 e-mail feedback sessions

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We followed our traditional process, which consists of 7 production steps and 4 intermediate review steps. The project involved quite complex molecular animation, requiring us to utilize several computational biology methods We gradually increased the complexity and accuracy of the most resource-consuming scenes, involving peptide-drug conjugates and membrane lipids, to ultimately create a scientifically rigorous visualization. This approach gives our clients a full control over the result.

Our extensive experience and collection of well-assembled 3D assets in molecular, cellular, and anatomical structures enabled us to focus more on the most complex and unique aspects of the project. As a result, we were able to complete them within the short time frame.

Why we used this animation type?

In this project, we visualized the mechanism of action of peptide drug conjugates capable of selectively targeting tumor tissues based on the tumor cell microenvironment's acidity. This required extensive advanced modeling and the involvement of computational biology methods to showcase the membrane dynamics and conformational changes of the peptide.

To achieve this, we utilized our most advanced High-End 3D style for the animation's key scenes. However, for the introductory scenes that provided context, we opted for our least resource-consuming, yet still eye-catching and highly effective semistatic 3D style. This decision allowed us to save production time and resources for our client without compromising on quality.