MoA for Antibody-Drug Conjugate Targeting TGF-β
MoA for Antibody-Drug Conjugate Targeting TGF-β
MoA for Antibody-Drug Conjugate Targeting TGF-β
MoA for an
Antibody-Drug Conjugate
Targeting TGF-β
Client:
Bicara Therapeutics is a clinical-stage biopharmaceutical company pioneering bifunctional antibody therapies for solid tumors. Their lead program, ficerafusp alfa (BCA101), is designed to simultaneously block tumor-promoting pathways and activate the immune system by targeting EGFR and neutralizing TGF-β. By combining targeted delivery with immune modulation, Bicara aims to improve treatment efficacy and overcome resistance in cancer therapy. The company is backed by leading investors and continues to advance innovative solutions in oncology.
Bicara Therapeutics is a clinical-stage biopharmaceutical company pioneering bifunctional antibody therapies for solid tumors. Their lead program, ficerafusp alfa (BCA101), is designed to simultaneously block tumor-promoting pathways and activate the immune system by targeting EGFR and neutralizing TGF-β. By combining targeted delivery with immune modulation, Bicara aims to improve treatment efficacy and overcome resistance in cancer therapy. The company is backed by leading investors and continues to advance innovative solutions in oncology.
Bicara Therapeutics is a clinical-stage biopharmaceutical company pioneering bifunctional antibody therapies for solid tumors. Their lead program, ficerafusp alfa (BCA101), is designed to simultaneously block tumor-promoting pathways and activate the immune system by targeting EGFR and neutralizing TGF-β. By combining targeted delivery with immune modulation, Bicara aims to improve treatment efficacy and overcome resistance in cancer therapy. The company is backed by leading investors and continues to advance innovative solutions in oncology.
Bicara Therapeutics is a clinical-stage biopharmaceutical company pioneering bifunctional antibody therapies for solid tumors. Their lead program, ficerafusp alfa (BCA101), is designed to simultaneously block tumor-promoting pathways and activate the immune system by targeting EGFR and neutralizing TGF-β. By combining targeted delivery with immune modulation, Bicara aims to improve treatment efficacy and overcome resistance in cancer therapy. The company is backed by leading investors and continues to advance innovative solutions in oncology.
Client:
Project Goal
Project Goal
Project Goal
Project Goal
Bicara Therapeutics needed a concise and visually compelling way to communicate the dual mechanism of action of its antibody–drug conjugate, which targets EGFR and neutralizes TGF-β in solid tumors. The goal was to illustrate how this therapy not only directly inhibits tumor growth but also remodels the tumor microenvironment—enhancing effector immune cells, reducing regulatory immune cells, and promoting anti-tumor immunity. The animation, developed in parallel with a static infographic, was intended for use on Bicara’s website and in corporate presentations, making it essential to balance scientific accuracy with visual clarity and accessibility.
Immune suppressive microenvironment with Regulatory T cells and M2 Tumor-associated Macrophages (TAM)
Immune suppressive microenvironment with Regulatory T cells and M2 Tumor-associated Macrophages (TAM)
Immune suppressive microenvironment with Regulatory T cells and M2 Tumor-associated Macrophages (TAM)
TGF-β binds to TGF-βR on the tumor cells
TGF-β binds to TGF-βR on the tumor cells
TGF-β binds to TGF-βR on the tumor cells
Ficerafusp alfa
Ficerafusp alfa
Ficerafusp alfa
“I liked working with the team and I enjoyed the creative process. Team worked well under tight timelines.
The animation created by Visual Science clearly demonstrated the mechanism of action of our therapeutic within the context of a complex tumor microenvironment. This brought our story to life in a creative and visually stimulating way”
“I liked working with the team and I enjoyed the creative process. Team worked well under tight timelines.
The animation created by Visual Science clearly demonstrated the mechanism of action of our therapeutic within the context of a complex tumor microenvironment. This brought our story to life in a creative and visually stimulating way”
“I liked working with the team and I enjoyed the creative process. Team worked well under tight timelines.
The animation created by Visual Science clearly demonstrated the mechanism of action of our therapeutic within the context of a complex tumor microenvironment. This brought our story to life in a creative and visually stimulating way”
“I liked working with the team and I enjoyed the creative process. Team worked well under tight timelines.
The animation created by Visual Science clearly demonstrated the mechanism of action of our therapeutic within the context of a complex tumor microenvironment. This brought our story to life in a creative and visually
stimulating way”
Senior Director, Translational Medicine, Biomarkers, Immunotherapy
Senior Director, Translational Medicine,
Biomarkers, Immunotherapy
Senior Director, Translational Medicine, Biomarkers, Immunotherapy
Ficerafusp alfa blocks both EGFR and TGF-β, aiming to remodel the tumor microenvironment
Ficerafusp alfa blocks both EGFR and TGF-β, aiming to remodel the tumor microenvironment
Ficerafusp alfa blocks both EGFR and TGF-β, aiming to remodel the tumor microenvironment
Cancer-Associated Fibroblasts (CAFs)
Cancer-Associated Fibroblasts (CAFs)
Cancer-Associated Fibroblasts (CAFs)
EGFR signaling blocked by Ficerafusp alfa
EGFR signaling blocked by Ficerafusp alfa
EGFR signaling blocked by Ficerafusp alfa
The Process
The Process
The Process
The Process
Animation type:
Animation type:
Animation type:
3D
3D
3D
Project timline:
Project timline:
Project timline:
4 weeks
4 weeks
4 weeks
Review:
Review:
Review:
2 zoom calls + 5 e-mail feedback sessions
2 zoom calls + 5 e-mail feedback sessions
2 zoom calls + 5 e-mail feedback sessions
Find out which of our 26 scientific animation options works best for investor relations and communications:
Find out which of our 26 scientific animation options works best for investor relations and communications:
Find out which of our 26 scientific animation options works best for investor relations and communications:
To deliver both scientific fidelity and production speed, we created the animation and infographic using a unified visual style. The same 3D models and visual elements were used across both formats, ensuring visual consistency. Camera movement and dynamic storytelling brought the infographic to life, maintaining continuity across media. We developed a unique animation format—Cellular 3D—that enabled schematic-level storytelling while preserving molecular accuracy. The final asset was optimized for cross-platform performance.
Cellular 3D Style: A hybrid approach combining infographic clarity with high-resolution 3D models of key molecules (EGFR, TGF-β, and the antibody–drug conjugate [ADC]).
Scientific Precision: Molecular components were modeled at atomic resolution, while supporting visuals remained clean and schematic.
Web Optimization: Delivered as a <5 MB file that autoplays without external players, ensuring mobile compatibility.
Brand Integration: Colors and visual styles were aligned with the client’s new branding in collaboration with their design agency.
Why did we use this
animation type?
Why did we use this
animation type?
Why did we use this
animation type?
The Cellular 3D format was chosen to balance scientific integrity with high-level storytelling. It provided a middle ground between simple 2D explainer videos and complex high-end 3D medical animations, enabling efficient production while still showcasing critical molecular interactions. This format was ideal for communicating complex mechanisms in a way that felt modern, on-brand, and informative—without overwhelming the audience.
Outcome:
Outcome:
Outcome:
The final animation successfully visualized Bicara’s bifunctional therapy in a manner that was both scientifically accurate and visually engaging. It aligned seamlessly with the accompanying static infographic, reinforced the company’s updated branding, and supported communication goals for investors and other stakeholders through scientific content development services. The lightweight, web-friendly format made the asset easy to deploy across platforms, while the Cellular 3D style established a new visual standard for rapid, precise scientific storytelling.
Full animation
Full animation
Full animation
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“Fantastic team to partner with throughout the entire process. Excellent output and management!”
"Visual Science produced an excellent website with incredible imagery, working in a professional, efficient manner to create a stunning final product! They were engaged through every step of the process and were attentive to the ideas we had in mind for our website. They continue to work with us on all updates and requests in a timely and helpful manner!"
“Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
“We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.
“Visual Science has a unique ability to communicate complex science with both accuracy and visual impact. Their team combines scientific understanding with creativity, helping bring sophisticated biomedical concepts to life.”
“We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
“I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
"Visual Science was a great partner in the development and delivery of scientific animations; the combination of their understanding of the science and their artistic expertise resulted in a visually stunning and impactful video."
“Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
“Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
“We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
“The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
“The creativity, scientific competency and professionalism of the Visual Science team not only enabled the generation of high-quality images, but also made it a pleasure to work with them.”
"Incredible animations that really help bring our science to life. I strongly recommend Visual Science!"
“The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
"We were impressed with the Visual Science team's attention to detail and ability to extract key messages out of a complex scientific story. Their deep understanding of the science enabled them to turn our cryo-EM structures into a beautiful visual that shows the key aspects of the bridge recombination mechanism."
"The Visual Science team did an outstanding job delivering beautiful MOA videos for us. The animations and attention to detail were exceptional, and their flexibility throughout the process made a huge difference."
"Excellent work by the Visual Science team!"
"Excellent work and project management."
"Visual Science produces high quality animations to support our unique science with agility and speed. I do value their partnership and look forward to working on more projects with them."
"The VS team was outstanding to work with on this project. From the outset, the level of communication, organization, and attention to detail was exceptional. The VS team moved a complication MoA project forward on-schedule, with scientific rigor, and the result was a beautifully composed video that distilled complex biology in a visually accurate way. I highly recommend this team."
"Thank you very much for such a great deliverable on a very tight timeline. I have been doing things like this for a long time and your incorporation of the Atsena insights to this with a very fast turnaround is very much appreciated and impressive."
"Very responsive and efficient. Thank you!"
Contact us
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“Fantastic team to partner with throughout the entire process. Excellent output and management!”
"Visual Science produced an excellent website with incredible imagery, working in a professional, efficient manner to create a stunning final product! They were engaged through every step of the process and were attentive to the ideas we had in mind for our website. They continue to work with us on all updates and requests in a timely and helpful manner!"
“Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
“We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.
“Visual Science has a unique ability to communicate complex science with both accuracy and visual impact. Their team combines scientific understanding with creativity, helping bring sophisticated biomedical concepts to life.”
“We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
“I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
"Visual Science was a great partner in the development and delivery of scientific animations; the combination of their understanding of the science and their artistic expertise resulted in a visually stunning and impactful video."
“Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
“Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
“We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
“The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
“The creativity, scientific competency and professionalism of the Visual Science team not only enabled the generation of high-quality images, but also made it a pleasure to work with them.”
"Incredible animations that really help bring our science to life. I strongly recommend Visual Science!"
“The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
"We were impressed with the Visual Science team's attention to detail and ability to extract key messages out of a complex scientific story. Their deep understanding of the science enabled them to turn our cryo-EM structures into a beautiful visual that shows the key aspects of the bridge recombination mechanism."
"The Visual Science team did an outstanding job delivering beautiful MOA videos for us. The animations and attention to detail were exceptional, and their flexibility throughout the process made a huge difference."
"Excellent work by the Visual Science team!"
"Excellent work and project management."
"Visual Science produces high quality animations to support our unique science with agility and speed. I do value their partnership and look forward to working on more projects with them."
"The VS team was outstanding to work with on this project. From the outset, the level of communication, organization, and attention to detail was exceptional. The VS team moved a complication MoA project forward on-schedule, with scientific rigor, and the result was a beautifully composed video that distilled complex biology in a visually accurate way. I highly recommend this team."
"Thank you very much for such a great deliverable on a very tight timeline. I have been doing things like this for a long time and your incorporation of the Atsena insights to this with a very fast turnaround is very much appreciated and impressive."
"Very responsive and efficient. Thank you!"
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
Contacts
Address
200 Vesey Street, 24th floor,
New York, NY 10281, USA
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
Contacts
Address
200 Vesey Street, 24th floor, New York, NY 10281, USA
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
Contacts
Address
200 Vesey Street, 24th floor,
New York, NY 10281, USA
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
Contacts
Address
200 Vesey Street, 24th floor,
New York, NY 10281, USA
© 2026, Visual Science. All rights reserved.
