Bridge RNAs: mechanism of action
Client:
Arc Institute is a nonprofit research organization that operates in partnership with Stanford University, UCSF, and UC Berkeley.
Arc Institute is a nonprofit research organization that operates in partnership with Stanford University, UCSF, and UC Berkeley.
Client:
Project Goal
Create an explainer MoA animation about the Bridge RNAs - a newly discovered, highly promising DNA editing tool.
Transposons in the bacterial genome
Donor DNA with transposases and bridge RNAs
Active site inside the transposase complex
“We were impressed with the Visual Science team’s attention to detail and ability to extract key messages out of a complex scientific story. Their deep understanding of the science enabled them to turn our cryo-EM structures into a beautiful visual that shows the key aspects of the bridge recombination mechanism.”
“We were impressed with the Visual Science team’s attention to detail and ability to extract key messages out of a complex scientific story. Their deep understanding of the science enabled them to turn our cryo-EM structures into a beautiful visual that shows the key aspects of the bridge recombination mechanism.”
Co-Founder and Core Investigator at the Arc Institute
and Assistant Professor of Bioengineering and Deb Faculty Fellow
at the University of California, Berkeley
DNA insertion
Transposase dimers on genomic DNA
Bridge RNA loops reprogramming
The Process
Animation type:
3D + High End 3D
Project timline:
7 weeks
Review:
3 zoom calls + 7 e-mail feedback sessions
Team:
Find out which of our 26 scientific animation options works best for investor relations and communications:
This animation illustrates the recent discovery by a team of scientists from the Arc Istitute and collaborators from the University of Tokyo, UC Berkeley, and Stanford. The animation's topic involves cutting-edge high-science research, so it required a very intense and rigorous effort from our scientific department.
We had to consider a plethora of details to ensure that every molecular model and sequence was accurate, and all the depictions of processes were correct. We are glad to have achieved such an accurate and beautiful result. The project timeline was very limited, requiring completion in time for publication of the client's scientific results in Nature.
Why did we use this
animation type?
Sophisticated molecular animations always require our High-end 3D style. In this case, we were showcasing very complex molecular interactions from the recombination process. We received partial intermediate PDB structures from client-side scientists and conducted a substantial amount of molecular modeling.
For some scenes, we used our Deck3D approach, based on more static visualizations, made more dynamic with 3D compositing and 2D animation tools. Based on the animation, we also created a set of additional illustrations, some of which were used as a cover proposal for Nature.
Full animation
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Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
