The collaboration includes ROME Therapeutics, a biotech company leveraging insights from dark genome biology to develop breakthrough therapies, and scientists from a number of high-profile academic institutions.
Series B
—
$199M raised
Project Goal
Create a scientifically accurate animation to present the recently-discovered structure of LINE-1 reverse transcriptase, and its potential for future drug discovery.
LINE-1 ORF2 reverse transcriptase enzyme
Reverse transcription in the nucleus
LINE-1 mRNA in the nucleus
LINE-1 ribonucleoprotein (RNP) complex
RNA-DNA hybrid with cGAS molecules attached
Activity and inhibition of LINE-1 reverse transcriptase
The Process
Animation type:
3D + High End 3D
Project timline:
13 weeks
Review:
10 zoom calls + 7 e-mail feedback sessions
Find out which of our 26 scientific animation options works best for investor relations and communications:
We completed this project for a team of researchers from various scientific and medical institutions and biotech firm ROME Therapeutics. The team published a remarkable study in Nature, describing the structure of LINE-1 reverse transcriptase - an enzyme that can produce potentially harmful genomic insertions and pro-inflammatory cytoplasmic RNA-DNA hybrids. Our work on this project required maximum dedication from every member of our team, and the communication process included a lot of input from multiple science specialists on the client's side, reflecting the demands of medical communication solutions for biotech teams working with complex research. We took meticulous care to implement all our client's ideas and comments. For this reason, the project took quite a lot of time and required extensive 3D modeling R&D - but in the end, we achieved a scientifically-accurate and visually outstanding result.
Why did we use this
animation type?
This animation focuses on very complex molecular processes and structures, requiring our most advanced modeling approaches and high-end 3D style. Since the animation was primarily targeted at scientists, the result had to be accurate and sophisticated at every level, from the script to the model details, placing it among our most technically demanding scientific animations.
At the same time, the video is brief, and to some extent plays the role of an artistic abstract for the research paper, so we had to delicately unite scientifically rigorous modeling and effective storytelling. Our team worked in close collaboration with the client-side researchers, who provided us with consultations and reference structures allowing us to update our molecular assets and visualize complex scenes with reverse transcription.
