High-end animation: LINE-1 reverse transcriptase
Client:
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The collaboration includes ROME Therapeutics, a biotech company leveraging insights from dark genome biology to develop breakthrough therapies, and scientists from a number of high-profile academic institutions.
Series B
—
$199M raised
Project Goal
Create a scientifically accurate animation to present the recently-discovered structure of LINE-1 reverse transcriptase, and its potential for future drug discovery.
LINE-1 ORF2 reverse transcriptase enzyme
Reverse transcription in the nucleus
LINE-1 mRNA in the nucleus
“The animation depicting the LINE-1 lifecycle is both visually remarkable and scientifically accurate – we were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
“The animation depicting the LINE-1 lifecycle is both visually remarkable and scientifically accurate – we were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President, CEO and co-founder, ROME Therapeutics
“Together with Visual Science, we created a compelling and captivating video that clearly explains complicated concepts in a short amount of time. I've had the chance now to show the video at a few meetings, and jaws dropped. The Visual Science team was also amazing to work with! Through the process, we were able to iterate and expand on a few key areas that only became apparent once we got into the animation. The end result speaks for itself!”
“Together with Visual Science, we created a compelling and captivating video that clearly explains complicated concepts in a short amount of time. I've had the chance now to show the video at a few meetings, and jaws dropped. The Visual Science team was also amazing to work with! Through the process, we were able to iterate and expand on a few key areas that only became apparent once we got into the animation. The end result speaks for itself!”
Massachusetts General Hospital & Harvard Medical School
LINE-1 ribonucleoprotein (RNP) complex
RNA-DNA hybrid with cGAS molecules attached
Activity and inhibition of LINE-1 reverse transcriptase
The Process
Animation type:
3D + High End 3D
Project timline:
13 weeks
Review:
10 zoom calls + 7 e-mail feedback sessions
Team:
Find out which of our 26 scientific animation options works best for investor relations and communications:
We completed this project for a team of researchers from various scientific and medical institutions and biotech firm ROME Therapeutics. The team published a remarkable study in Nature, describing the structure of LINE-1 reverse transcriptase - an enzyme that can produce potentially harmful genomic insertions and pro-inflammatory cytoplasmic RNA-DNA hybrids. Our work on this project required maximum dedication from every member of our team, and the communication process included a lot of input from multiple science specialists on the client's side. We took meticulous care to implement all our client's ideas and comments. For this reason, the project took quite a lot of time and required extensive 3D modeling R&D - but in the end, we achieved a scientifically-accurate and visually outstanding result.
Why did we use this
animation type?
This animation focuses on very complex molecular processes and structures, requiring our most advanced modeling approaches and high-end 3D style. Since the animation was primarily targeted at scientists, the result had to be accurate and sophisticated at every level, from the script to the model details.
At the same time, the video is brief, and to some extent plays the role of an artistic abstract for the research paper, so we had to delicately unite scientifically rigorous modeling and effective storytelling. Our team worked in close collaboration with the client-side researchers, who provided us with consultations and reference structures allowing us to update our molecular assets and visualize complex scenes with reverse transcription.
Full animation
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10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
“
Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
“
Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
“
Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
“
Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
Contact us
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
“
Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
“
Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
“
Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
“
Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
Contact us
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Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
