3D MoA Animation
on IL-13 Signaling
and Inhibition
Client:
Apogee Therapeutics is a clinical-stage biotechnology company that discovers and develops novel therapies for a range of inflammatory and immunological diseases. The company seeks to achieve this by focusing on established biologic drivers of disease and applying advanced antibody engineering to create product candidates with optimized properties that may overcome the limitations of existing therapies.
Apogee Therapeutics is a clinical-stage biotechnology company that discovers and develops novel therapies for a range of inflammatory and immunological diseases. The company seeks to achieve this by focusing on established biologic drivers of disease and applying advanced antibody engineering to create product candidates with optimized properties that may overcome the limitations of existing therapies.
Client:
Project Goal
The goal of this project was to develop a clear, scientifically accurate MoA animation showing how IL-13 drives type 2 inflammation and how zumilokibart interrupts this pathway. The animation translated complex signaling, receptor interactions, and antibody recycling into a concise, structured narrative for clinicians, researchers, and stakeholders, while highlighting both mechanism and therapeutic durability.
Cellular internalization of the modified antibody and binding to FcRn
Antibody with YTE modification
IL-13 binding to cell surface receptors
“Incredible animations that really help bring our science to life. I strongly recommend Visual Science!”
“Incredible animations that really help bring our science to life. I strongly recommend Visual Science!”
The Process
Animation type:
3D + High End 3D
Project timline:
8 weeks
Review:
8 zoom calls + 4 e-mail feedback sessions
Team:
Find out which of our 26 scientific animation options works best for investor relations and communications:
We began by studying the IL-13 signaling pathway and the mechanism of action of zumilokibart, developing an initial script that translated cytokine-driven inflammation, receptor interactions, and antibody engineering into a clear visual narrative. After aligning with the client and incorporating feedback, we moved into production following a structured pipeline from storyboards to animatics and final renders, with Visual Science leading execution while the client reviewed key milestones and provided targeted input.
To clearly communicate both the biology and therapeutic differentiation, we developed a multi-scale visual system that progresses from a simplified systemic view of IL-13 into detailed cellular and molecular interactions. A consistent visual language, supported by color coding, was used to distinguish IL-13, its receptors, and the therapeutic antibody, ensuring clarity as the animation moved from receptor binding to pathway inhibition. We further introduced focused molecular sequences to illustrate antibody internalization and FcRn-mediated recycling enabled by YTE modification, followed by integrated pharmacokinetic visuals to reinforce extended half-life and reduced dosing frequency, maintaining a cohesive and scalable visual framework throughout.
Outcome
The final animation clearly communicated IL-13–driven inflammation and how zumilokibart interrupts this pathway, combining molecular detail with accessible storytelling. It highlighted key advantages such as extended half-life and reduced dosing frequency, resulting in a versatile asset for scientific, investor, and stakeholder communication.
Full animation
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We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
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The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
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Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
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Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
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The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
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I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
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We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
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The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
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Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
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We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
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Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
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Fantastic team to partner with throughout the entire process. Excellent output and management.
Global Marketing Director, Pfizer
10/10
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We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
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We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
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The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
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Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
10/10
“
Fantastic team to partner with throughout the entire process. Excellent output and management.
Global Marketing Director, Pfizer
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
“
Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
10/10
“
Fantastic team to partner with throughout the entire process. Excellent output and management.
Global Marketing Director, Pfizer
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
“
Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
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10/10
“
Fantastic team to partner with throughout the entire process. Excellent output and management.
Global Marketing Director, Pfizer
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
“
Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
10/10
“
Fantastic team to partner with throughout the entire process. Excellent output and management.
Global Marketing Director, Pfizer
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
“
Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
10/10
“
Fantastic team to partner with throughout the entire process. Excellent output and management.
Global Marketing Director, Pfizer
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
“
Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
10/10
“
Fantastic team to partner with throughout the entire process. Excellent output and management.
Global Marketing Director, Pfizer
10/10
“
We are very pleased with Visual Science — they are a very responsive group to work with and the final product is exactly what we had envisioned.”
CEO, Atsena Therapeutics
10/10
“
The scientific expertise really showed in the discussions and final products. Everybody was responsive and great to work with, and the animations were both engaging and accurate!”
Program Manager, American Chemical Society
10/10
“
Visual Science team has just the right blend of scientific acumen and digital animation expertise to pull off these challenging projects.”
CEO, Apton Biosystems
9/10
“
Visual Science is a fantastic partner, capable of rendering the most complex science in compelling ways. They understood the science, and their production was excellent.”
VP, Head of Communications, Scorpion Tx
7/10
“
The structural biology models from Visual Science are stunning! Visual Science implemented our guidelines into beautiful scientific imagery for our website and scientific slide decks.”
Science Content Lead, Dewpoint Tx
9/10
“
I was very impressed with scientific knowledge of the Visual Science team, which led to a fantastic visualization of the MOA of our drug. Attention to scientific details was extraordinary.”
Vice President, R&D, Unicycive Tx
10/10
“
We were impressed by the scientific sophistication of the Visual Science team and their skill in capturing the concepts we wanted to communicate. The final video was exceptional.”
CSO, Enterin
10/10
“
The quality of the work from Visual Science was outstanding. They provide a bespoke service that was responsive to our requests and I would recommend them highly.”
CEO, UNITY Biotechnology
10/10
“
Beautiful work that is detailed and thoughtful. Great final output.”
Sr. Comms & IR Associate, Candel Tx
10/10
“
We were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.”
President & CEO, ROME Tx
10/10
“
Excellent scientific partner and first class imagery. This team runs a tight ship and the process is clear. The tech and final product are first rate.”
VP, Corp Dev, Revolution Medicines
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
Visual Science is an award-winning medical animation and digital scientific communications company, trusted by leading biotech and pharmaceutical organizations since 2007, including J&J, Pfizer, Novartis, Roche, Takeda, Gilead, AbbVie, and 100+ others.
We specialize in science-grade MoA and MoD videos, medical animation, and scientific storytelling, as well as digital and AI-driven solutions for Medical Affairs, marketing, corporate communications, and investor relations.
© 2026, Visual Science. All rights reserved.
