Wound debridement platform technology mechanism of action

MediWound is the global leader in next-generation enzymatic therapeutics for non-surgical tissue repair, and is engaged in the development, production and commercialization of solutions to replace existing standards of care. MediWound is committed to improving patient experiences and outcomes by providing rapid and effective biologics, simultaneously cutting costs and reducing unnecessary surgical interventions.

MDWD (NASDAQ)

Project goal

Create a short animation to explain the mechanism of action of one of the client's products based on proteolytic enzyme mixture.

Bromelain molecule in the enzyme mixture

Collagen and fibrin fibers in normal tissue

Necrotic tissue and enzyme action

"I liked the Visual Science team's responsiveness to our requests and ability to meet all time tables. Interaction with the team was professional, concise, easy-going and never cumbersome. We were not require to provide any scientific references - it was seamlessly done for us and the outcome was rather accurate with only minor finetuning required.

A high-quality MOA animation, properly executed, we are very pleased with the outcome!”

Ofer Gonen

Chief Executive Officer, MediWound

Enzymes in action

Bacteria on top of necrotic tissue

Processed damaged tissue and clean wound bed

The Process

Animation type:

3D + High End 3D

Project timline:

7 weeks

Team

Review:

5 zoom calls + 4 e-mail feedback sessions

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For this project, we followed our traditional pipeline, starting from animated storyboards and gradually increasing the visuals' complexity through a series of 3D animatics. Each iteration was discussed with the MediWound team, and we carefully collected their feedback before implementing all comments in later versions. Modeling of the different types of damaged and necrotic skin tissue at a range of magnification levels was challenging, but the resulting visuals turned out to be balanced, accurate, and eye-catching. Our in-house practising dermatologist selected only the most relevant references to be used in modeling. The Visual Science team includes a number of experts in key biomedical fields, ensuring that we maintain a high level of scientific accuracy in our work.
Our extensive experience and collection of well-assembled 3D assets in molecular, cellular, and anatomical structures enabled us to focus more on the most complex and unique aspects of the project. As a result, we were able to complete them within the short time frame.

Why we used this animation type?

In order to demonstrate all the aspects of MediWound's technology, we had to model and visualize multiple complex objects from the molecular to tissue levels. For this reason, we used a combination of our High-End 3D and main 3D animation styles. The first, more advanced style was used for shots at the molecular level, while main 3D worked best for the visualizations of skin tissues and cells. The animation's topic required visualization of objects like slough and necrotic tissue, which cannot be considered particularly appealing visually. Through our lookdev and modeling processes, we tried multiple options to make the visuals more neutral and clean, and eventually developed a style which delivered a result which was both attractive and uncompromising on details and accuracy.