Different types of allergies have a huge impact on human health worldwide. Adverse drug reactions may affect up to 10% of the world’s population and affect up to 20% of all hospitalized patients; about 9% of toddlers aged 3-5 years have a food allergy; and the rise in prevalence of allergic diseases has continued in the industrialized world for more than 50 years (link).
Selecta Biosciences and Selecta RUS produce and distribute a new class of targeted tolerogenic vaccines based on the tSVP™ platform that helps regulate antigen-specific immune activation or induce antigen-specific immune tolerance. The vaccines are based on the combination of the antigen and immunosuppressor encapsulated in one biodegradable nanoparticle. The tolerogenic effect develops after the simultaneous administration of both agents to dendritic cells that induce the growth of the regulatory T-cells population thus attenuating the immune response for the allergen.
Other Selecta Biosciences drug development programs include universal human papillomavirus vaccine, universal influenza vaccine, malaria vaccine, and type 1 diabetes therapeutic vaccine.
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