Mechanism of action of the tumor-specific drug
Client:
Cybrexa Therapeutics
Date:
19.12.2017
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Cybrexa Therapeutics was founded by world-renowned physician-scientists from Yale University and serial biotech entrepreneurs. The company is developing a new class of small molecule DNA repair inhibitors that directly target cancer tumor microenvironments. To explain the inhibitors’ mechanism of action to investors and a wider audience, Cybrexa hired Visual Science to create a short 3D animation for presentations and website.

The animation presents the novel tumor-localizing peptide technology for drug delivery. In healthy human tissue with neutral pH, the drug-containing peptide is loosely associated with the cell membrane, and the drug is not released. However, because of their metabolisms, tumor cells lower the pH level around them. In the presence of low pH, the peptide forms an alpha helix and translocates across the cell membrane, releasing the drug directly into the cell cytoplasm. Thus, the drug affects only the target tumor cells without damaging healthy tissues.

The Cybrexa Therapeutics tumor-localizing DNA repair inhibitors can be combined with chemotherapy and radiotherapy, allowing higher drug doses to be delivered both safely and with enhanced efficacy.



Visual Science’s Ebola Poster represents a pinnacle in the history of visualization of the human body.
Lewis Sadler MA, Msc.
Chief Science Officer at Visible Productions Inc., Research Assistant Prof. University of Illinois at Chicago, (US)