Mechanism of action of selective serotonin
reuptake inhibitor (SSRI)

Serotonin, or 5-hydroxytryptamine (5-HT), acts as a hormone and as a neurotransmitter in humans. Most of the serotonergic neurons reside in the hypothalamus and limbic system of the human brain.

Following a neuronal impulse, conduction neurotransmitters are released into the synaptic cleft, and they bind receptors on the postsynaptic membrane. The process is terminated either by degradation (in this particular case by monoaminoxidase (MAO) or catechol-O-methyltransferase (COMT)) or reuptake of the neurotransmitters by the corresponding receptors on the presynaptic membrane. SSRIs (selective serotonin reuptake inhibitors) bind to post-synaptic 5-HT receptors and function as competitive antagonists that increase the levels of serotonin in the synaptic cleft and thus, enhance stimulus conduction. This effect is used in the synthesis of new psychotic compounds for the treatment of depression, anxiety disorders, and some personality disorders.

Client

Hemopharm

Date: Oct 22, 2008

Testimonials

Designers and scientific consultants from Visual Science company demonstrate deep understanding of the subject and high level of professionalism resulting in remarkable quality of the product. Visual Science’s graphics is widely used in all presentational materials of the RUSNANO Corporation, including videos, brochures, press-releases and web-sites
A.V. Trapeznikov, Corporate director, Board member of RUSNANO
Wiley
Project Inquiry

Tell us how to reach you and we’ll contact you shortly

Your request was sent. Thank you for your interest!