Innovative anticancer drugs
Client:
RUSNANO
Date:
05.12.2012
Anticancer drug based on an adenovirus vector - mechanism of action
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Cells become malignant due to accumulation of specific mutations. New mutations occur in cells permanently throughout their lifespan. Normally, the immune system recognizes and destroys cancer cells but this process is not always effective. Cancer cells do not senesce or undergo apoptosis because both processes are disrupted in malignant cells. Instead they become capable of uncontrolled growth and division, and gain the ability to invade neighboring tissues.

  • Adenovirus model

    Adenovirus vector

One of the strategies used in cancer therapy is to improve identification of cancer cells by the immune system. This approach was used in developing a new drug called Mobilan made by Panacela with the support of Cleveland BioLabs and RUSNANO. The mechanism of action of the drug is based on delivery to the tumor cells of two genes encoding flagellin — a structural protein of bacterial flagellum. The genes are delivered to tumor cells by a non-pathogenic adenoviral vector particle. Flagellin is a familiar antigen for the immune system and once its genes reach the tumor cells the immune response against the malignant tissue is induced: TLR5, the toll-like receptor, recognizes flagellin and triggers the production of cytokines which attract and activate immune cells. The exact mechanism of the activation of immune system by Mobilan and the possibility to use the flagellin-TLR5 based scheme in therapy of some non-oncogenic disorders are still under investigation. Our infographics demonstrate an overview of Mobilan’s possible mechanism of action.

  • Anticancer drug mechanism of action

    Working principle of Mobilan

Cooperation with RUSNANO

The Visual Science Company has cooperated with the RUSNANO Group since 2008, creating a wide range of high quality graphic information materials. Various infographics have been designed to demonstrate the technologies developed and implemented by RUSNANO project companies. The aim of each project is to demonstrate the principle of technology, nanotechnological components of the project and the advantages of the chosen solution compared with analogues.

The work of Visual Science is carried out in a single sheet or slide format. The modular structure of the infographics makes it possible to use it both as a whole piece or as separate components, which is convenient for preparing website illustrations or project reports or publications. Thus one material helps to solve almost all the issues with illustrating the information about the project.

The target audience for these graphics includes professionals in relevant areas, and a wide range of specialists in different fields without a technical background. Scientific accuracy, combined with the optimum degree of generalization allow for communicating equally effectively with target audiences with different background.

All the graphics have been used by the RUSNANO Group for 5 years or more. As usual, the feature of the Visual Science workflow includes the entire spectrum of tasks ranging from analyzing the scientific literature of the project to the preparation of the final graphics on the company’s side that allows saving valuable time of our customers.

I would like to express my gratitude to Visual Science and all its employees who participated in the Second Nanotechnology International Forum organization. Thank you for your professionalism and the high quality product
A.B. Chubais
CEO of SC "Rusnanotech" RUSNANO